2025 01 v.40 4-7
基于脑肠轴理论探讨少阳病实质
基金项目(Foundation):
福建省卫生健康青年科研课题(2023QNA080);
福建中医药大学校管课题项目(XB2021032)
邮箱(Email):
DOI:
10.13913/j.cnki.41-1110/r.2025.01.002
中文作者单位:
福建中医药大学附属第三人民医院;
摘要(Abstract):
基于脑肠轴理论，归纳了少阳病的三组症状，即“消化道症状”“精神症状”“其他或见症状”。认为足少阳胆、手少阳三焦的生理功能与脑肠轴理论相似，联系了少阳病三组症状的信号交互，是导致少阳病的主要机制。在治疗上借鉴脑肠轴理论，明确少阳病的病位及病性，剖析“和法”的本质。
关键词(KeyWords):
少阳病;脑肠轴;手少阳三焦;足少阳胆;少阳轴;张仲景学术学说研究
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参考文献
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[3] 郑嘉怡，潘华峰，赖新生，等.浅谈脾胃病中“脾胃”“脑”相关理论 [J].中华中医药杂志，2020,35(4):1691-1693.
[4] 仲海红，徐进友.从少阳论治呆病[J].中国中医基础医学杂志，2019,25(6):835-837.
[5] 王挺，莫慧，林立宇，等.“郁伏少阳”假说探讨抑郁症病因病机及证治 [J].陕西中医，2020,41(2):220-222.
[6] 王省，陈刚.试论枢转少阳与快速抗抑郁[J].中医杂志，2017,58(2):174-176.
[7] 李凌江，陆林.精神病学[M].3版.北京：人民卫生出版社，2015:376-377.
[8] MAES M,KUBERA M,OBUCHOWICZWA E,et al.Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways[J].Neuro endocrinology letters,2011,32(1):7-24.
[9] ALI FT,ABD EL-AZEEM EM,HAMED MA,et al.Redox dysregulation,immuno-inflammatory alterations and genetic variants of BDNF and MMP-9 in schizophrenia:Pathophysiological and phenotypic implications[J].Schizophrenia research,2017(188):98-109.
[10] DU Y,GAO XR,PENG L,et al.Crosstalk between the microbiota-gut-brain axis and depression[J].Heliyon,2020,6(6):e04097.
[11] ZONIS S,PECHNICK RN,LJUBIMOV VA,et al.Chronic intestinal inflammation alters hippocampal neurogenesis[J].Journal of neuroinflammation,2015,12:65.
[12] GHEORGHE CE,MARTIN JA,MANRIQUEZ FV,et al.Focus on the essentials:tryptophan metabolism and the microbiome-gut-brain axis[J].Current opinion in pharmacology,2019,48:137-145.
[13] GAO K,MU CL,FARZI A,et al.Tryptophan Metabolism:A Link Between the Gut Microbiota and Brain[J].Advances in nutrition (Bethesda,Md),2020,11(3):709-723.
[14] MA J,WANG F,YANG J,et al.Xiaochaihutang attenuates depressive/anxiety-like behaviors of social isolation-reared mice by regulating monoaminergic system,neurogenesis and BDNF expression[J].Journal of ethnopharmacology,2017,208:94-104.
[15] 张阔，杨静玉，吴春福.小柴胡汤对断乳后孤养应激抑郁模型的抗抑郁作用及机理[J].神经药理学报，2018,8(6):44-45.
[16] ZHANG K,YANG J,WANG F,et al.Antidepressant-like effects of Xiaochaihutang in a neuroendocrine mouse model of anxiety/depression[J].Journal of ethnopharmacology,2016,194:674-683.
基本信息:
DOI：10.13913/j.cnki.41-1110/r.2025.01.002
中图分类号:R228
引用信息:
[1]梁海,陈梨花.基于脑肠轴理论探讨少阳病实质[J].国医论坛,2025,40(01):4-7.DOI:10.13913/j.cnki.41-1110/r.2025.01.002.
基金信息:
福建省卫生健康青年科研课题(2023QNA080); 福建中医药大学校管课题项目(XB2021032)