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目的 基于中医传承辅助平台(V2.5)探讨三亚市中医院儿科中药治疗儿童呼吸道合胞病毒(RSV)肺炎的用药规律。方法 收集2020年1月—2024年12月三亚市中医院儿科住院治疗RSV肺炎患儿有效中药处方,将数据标准化录入中医传承辅助平台(V2.5),运用数据挖掘方法探讨其用药规律,并挖掘出高频药物组合和生成新方。结果 纳入分析198例患儿,共纳入处方385首,首先主要为痰热闭肺证处方307首(79.7%),其次为肺脾气虚证处方72首(18.7%)。痰热闭肺证处方共涉及125味中药,四气中寒性药频次最高,其次为温性药;五味集中于辛、苦、甘;归经以肺经为首,其次归胃、脾经;数据分析产生13味核心中药、2个可用新方。肺脾气虚证处方共涉及77味中药,四气中温性药频次最高;五味集中于甘、苦、辛;归经主要归肺经,其次归脾、胃经;数据分析产生8味核心中药。结论 儿童RSV肺炎住院患者证型最多为痰热闭肺证,其次为肺脾气虚证。陈皮-茯苓为治疗儿童RSV肺炎必选药对。治疗痰热闭肺证予苦寒之药的同时要佐以甘温之品,以防苦寒伤胃;治疗肺脾气虚证予补益药的同时,要注意祛邪、祛痰。
Abstract:Objective To explore the medication patterns of traditional Chinese medicine(TCM) for treating respiratory syncytial virus(RSV) pneumonia in children in the pediatrics department of Sanya Traditional Chinese Medicine Hospital using the TCM Heritage Auxiliary Platform(V2.5). Methods Valid TCM prescriptions for RSV pneumonia in hospitalized children were collected from January 2020 to December 2024 and standardized into the TCM Heritage Auxiliary Platform(V2.5). Data mining methods were employed to explore medication patterns, identify high frequency drug combinations, and generate new prescriptions. Results A total of 198 cases were included, A total of 385 prescriptions were included, The first was the syndrome of phlegm-heat obstructing the lung(307 cases, 79.7%), followed by the syndrome of lung-spleen qi deficiency(72 cases, 18.7%). The syndrome of phlegm-heat obstructing the lung prescriptions involved 125 TCM herbs, with cold-natured herbs being the most frequent among the four natures, followed by warm-natured herbs. The five flavors were concentrated in pungent, bitter, and sweet; the primary meridian was the lung, followed by the stomach and spleen. Data analysis identified 13 core herbs and two new prescriptions. The syndrome of lung-spleen qi deficiency prescriptions involved 77 TCM herbs, with warm-natured herbs being the most frequent among the four natures. The five flavors were concentrated in sweet, bitter, and pungent; the primary meridian was the lung, followed by the spleen and stomach. Data analysis identified 8 core herbs. Conclusion The most common syndrome in hospitalized children with RSV pneumonia was the syndrome of phlegm-heat obstructing the lung, followed by the syndrome of lung-spleen qi deficiency. Tangerine peel and poria cocos were essential drug pairs for treating RSV pneumonia in children. When treating the syndrome of phlegm-heat obstructing the lung, bitter-cold herbs should be combined with sweet-warm herbs to prevent stomach injury from excessive bitterness and coldness. For the syndrome of lung-spleen qi deficiency, tonifying herbs should be used alongside pathogen removal and phlegm elimination.
[1] 毕陶然,徐钰,李冉,等.呼吸道合胞病毒感染的预防与治疗进展[J].中国病毒病杂志,2025,15(3):258-266.
[2] 顾丽娜,吕贞燕,项红霞.不同年龄儿童呼吸道合胞病毒肺炎的临床特征及混合感染危险因素分析[J].中国当代医药,2025,32(18):32-35.
[3] KARRON R A,BOGUNOVIC N,POLACK F P.Respiratory syncytial virus evolution and immunity[J].Nature Reviews Microbiology,2022,20(10):589-604.
[4] SUSS RJ,SIMOES EAF.Respiratory Syncytial Virus Hospital-Based Burden of Disease in Children Younger Than 5 Years,2015-2022[J].JAMA Netw Open,2024,7(4):e247125.
[5] 花少栋,周雪颖,张宁,等.《2025年香港儿童呼吸道合胞病毒预防实践建议》解读[J].中国临床医生杂志,2025,53(6):700-705.
[6] 陈兰举.儿科学[M].2版.合肥:中国科学技术大学出版社,2017:112.
[7] 汪受传,赵霞,韩新民,等.小儿肺炎喘嗽中医诊疗指南[J].中医儿科杂志,2008(3):1-3.
[8] 熊磊.中医儿科学[M].北京:人民卫生出版社,2020:98.
[9] 国家药典委员会.中华人民共和国药典:一部[M].北京:中国医药科技出版社,2020.
[10] 钟赣生,杨柏灿.中药学[M].5版.北京:中国中医药出版社,2021.
[11] 梁璐,高伟霞,曾苑,等.肺力咳合剂联合雾化吸入重组人干扰素α2b治疗RSV肺炎患儿的疗效与安全性研究[J].海南医学,2025,36(17):2490-2494.
[12] 王辉,王雪峰,李瑞雪,等.热毒宁治疗儿童呼吸道合胞病毒肺炎的Meta分析[J].中国现代医生,2025,63(17):47-51.
[13] KALER J,HUSSAIN A,PATEL K,et al.Respiratory syncytial virus:a comprehensive review of transmission,pathophysiology,and manifestation[J].Cureus,2023,15(3):e36342.
[14] 胡锦辉,陈细武.不同中医证型小儿合胞病毒肺炎的临床特点分析[J].四川中医,2023,41(5):100-102.
[15] 郑庆藩,徐嘉鸿,胡新娅.2023—2024年汕头地区儿童呼吸道感染的病原学和流行病学特征分析[J].中国妇幼保健,2025,40(20):3766-3771.
[16] 韦晓静,蔡晓静.小儿肺炎中医证型影响因素研究进展[J].国医论坛,2024,39(2):76-78.
[17] 李瑞雪,王雪峰,谭春迎,等.小儿定喘颗粒干预呼吸道合胞病毒肺炎(痰热闭肺证)的临床疗效观察[J].中国中西医结合儿科学,2025,17(1):87-91.
[18] 张超,高翡,林炜.金欣口服液抗呼吸道合胞病毒机制研究[J].南京中医药大学学报,2025,41(11):1596-1603.
[19] 杨燕,汪受传,李瑞丽.儿童呼吸道合胞病毒肺炎中医证型演变规律及临床意义[J].中国中医急症,2022,31(8):1345-1348.
[20] 宋金华.我国发热呼吸道症候群中人呼吸道合胞病毒的基因特征研究[D].北京:中国疾病预防控制中心,2018.
[21] 厉晓,龚婕,丁婵,等.茯苓多糖的结构、活性及其构效关系研究进展[J].中草药,2025,56(1):305-317.
[22] 张航,朱胜金,吴小梅,等.中药陈皮的临床应用及研究进展[J].贵州中医药大学学报,2025,47(5):40-44.
[23] 祝宏江,庞立健,王天娇,等.麻杏石甘汤治疗呼吸系统疾病研究进展及其质量标志物(Q-Marker)预测分析[J/OL].中华中医药学刊,1-15(2025-05-06)[2025-06-29].https://link.cnki.net/urlid/21.1546.R.20250506.1337.014.
[24] 孙新茹,李鑫蕊,王玉清,等.紫苏子化学成分和药理作用的研究进展及其质量标志物预测[J].天然产物研究与开发,2025,37(4):768-791.
[25] 张嘉欣,朱珠,孙念霞,等.桑白皮化学成分、药理作用研究进展及其质量标志物预测[J].中草药,2025,56(9):3340-3353.
[26] 焦艳,陈健,高振珅.葶苈子的临床应用及药理作用研究进展[J].中国民间疗法,2025,33(18):113-117.
[27] 杨万林,张樱山.二陈汤治疗呼吸系统疾病的研究现状[J].中国临床药理学杂志,2024,40(8):1236-1240.
[28] 付际游,商庆辉,姜琳,等.百部的功效、临床应用及现代药理作用研究进展[J].中国医药导刊,2025,27(9):896-901.
[29] 王帅,石燕红,王瑞,等.中药前胡中香豆素类化学成分及其分析方法、药理作用研究进展[J].上海中医药杂志,2022,56(9):89-99.
[30] 钟山,王东,王勇杰,等.五味子总木脂素对咳嗽高敏豚鼠的止咳作用及其机制研究[J].中成药,2023,45(7):2349-2353.
基本信息:
DOI:10.13913/j.cnki.41-1110/r.2026.03.017
中图分类号:R272
引用信息:
[1]陈杰奎,郑义雪,张振尊,等.基于数据挖掘探讨中药治疗儿童呼吸道合胞病毒肺炎用药规律[J].国医论坛,2026,41(03):32-38.DOI:10.13913/j.cnki.41-1110/r.2026.03.017.
基金信息:
海南省中医优势专科建设项目(琼卫中医函[2024]3号)
2026-05-20
2026-05-20